Sex-based differences on adverse left ventricular remodeling and clinical outcomes after an ST-segment elevation myocardial infarction in the PCI era

Abstract Background There is conflicting evidence regarding sex-based differences in myocardial salvage and clinical outcome patients after an ST-segment elevation infarction (STEMI) the contemporary era of primary percutaneous coronary intervention (PCI) optimal medical treatment. Adverse left ventricular remodelling (LVR) a STEMI worsens outcomes, however, influence sex not yet clear. Aim/Purpose To analyze whether there are outcomes adverse LVR STEMI. Methods Patients with who underwent PCI were included cardiac magnetic resonance (CMR) was performed during hospitalization (6.2±2.6 days) 6 months (6.1±1.8 months). LVR, (MS), infarct size (IS), microvascular obstruction (MVO), area at risk (AAR) quantified. defined as 15% increase LV end-diastolic volume relative fall ejection fraction 3% months. The composite cardiovascular death, admission for heart failure, or arrhythmia. Results A total 1046 (mean age: 59.8±9 years; 16.6% women), second CMR completed 589 patients. Women older (58.8±8 years vs 65.0±10 years, p<0.0001) presented more factors (Table). occurred 310 follow-up 75 (range: 36–112 months) frequent women than men (35.8% 22.3%, p<0.001). After adjusting baseline (age, diabetes, hypertension, Killip class, time to reperfusion), female independent predictor major events (Fig. 1A & B). Although strong outcome, no interaction present between (women 6.4% 8%, p=0.46) (Fig 1B), nor did we find significant other derived variables such MS, IS, MVO AAR. Conclusions STEMI, worse men. However, these related their characteristics higher incidence factors, remodeling. Funding Acknowledgement Type funding sources: None.